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A cDNA encoding nlscre was inserted after 7 kb fragment of the Flt4 (Vegfr3) gene promoter region from the BAC RPC123-118J11 in the targeting vector. The cre sequence was followed by a polyA signal sequence from the murine Pgk gene. This vector was purified and injected into pronuclei of fertilized C57BL/6J mice. Line 44 showed recombination in lymphatic endothelial cells when crossed to reporter mice. (J:159024)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
