A GFPCre expression cassette was inserted into the transcription start site (ATG) of the Prox1 genomic locus along with a neomycin selection cassette. A thymidine kinase negative-selection cassette was also included. The targeting construct was electroporated into W9.5 mouse ES cells. Following selection and screening via standard methods, correctly targeted ES cell clones were used to generate the chimeric mice. (J:158959)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intragenic deletion
--
1
--
16

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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