A floxed neomycin resistance cassette was inserted in intron 1 and a third loxP site was placed in intron 2 just downstream of exon 2. The selection cassette was then removed from properly targeted ES cells by transient cre expression. (J:159011)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count