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The allele was created by crossing heterozygous Bidtm1Ast mice with Tg(CMV-cre)1Cgn cre deleter mice to remove neo cassette, leaving a single loxP site and deleting approximately 4.5 kb region of the bid locus containing exons 1 and 2 plus part of exon 3, including the crucial BH3 domain. Western blot analysis on spleen and thymus samples and thymocytes derived from homozygous mice demonstrated that no detectable protein is produced from this allele. (J:158191)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
