Cre mediated recombination removed exons 3 through 8 of a MICER clone with a K14-Agouti gene, 3'Hprt, loxP site, and puro cassette inserted downstream of a duplicated exons 1 and 2 and a neo cassette, loxP site, 5'Hprt, and tyrosinase gene inserted downstream of exon 8. The absence of transcript expression was confirmed by RT-PCR analysis on hippocampus and cortex extracts. (J:158715)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S7/SvEvBrd-Hprt1b-m2
Targeted
Insertion, Intragenic deletion
--
1
4
5

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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