The genomic region coding for amino acids 2 through 315 of 321 amino acids was replaced with an inframe human cDNA with the nucleotide substitution resulting in the amino acid substitution of arginine for histidine at position 134 (H134R) fused to Venus and followed by a floxed self-excising neo cassette. Expression of the fusion protein in nonpeptidergic neurons was confirmed by immunohistochemistry. (J:158198)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Targeted
Insertion, Intragenic deletion
--
1
--
3

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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