Exon 9, which encodes the Zinc-binding domain of the protease active site, was flanked by loxP sites. The Neo cassette was removed from the germline by FLP mediated recombination. (J:158127)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count