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A human APP751 cDNA with a mutation in the codon for amino acid residue 693 causing a glutamic acid to glutamine change (E693Q) was place under the control of the murine Thy1.2 minigene. Five positive founder mice were identified. This record is for combined data from the two highest expressing lines, lines 23 and 33. Expression is five times higher than for endogenous APP. (J:92796)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
