An frt flanked neo cassette was inserted in intron 5, and exon 5 was flanked 5' and 3' with loxP sites 532 bp upstream and 934 bp downstream. The selection cassette was removed by flp mediated recombination. The amount of wild-type RNA is unchanged. (J:157997)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count