From 5' to 3' the tansgene contains a synthetic polyadenylation site, the rat myosin light chain 1 gene promoter, the cre recombinase gene modified to contain a Kozak consensus site immediately upstream of the start codon, intron and polyadenylation sites from the SV40 t antigen gene, and the rat myosin light chain 1/3 enhancer. A line was chosen that exhibited skeletal muscle-specific expression as determined by Northern analysis. (J:158173)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count