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A BAC derived 5.5 kb fragment of the Sprr2f promoter was cloned into a vector containing a cre coding sequence. Cre is expressed exclusively in endometrial epithelial cells and is naturally estrogen inducible due to the estrogen response elements in the Sprr2f regulatory region. The linearized construct was linearized and microinjected into FVB oocytes. Line 1 was assigned to this transgene in absence of specific line information. This transgene used different constructs compared to Tg(Sprr2f-cre)2Dcas generated by the same creator. (J:158190)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
