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cDNA encoding the C-terminal portion of the gene with A661C and N663C mutations, as well as a polyA-neo cassette, was inserted into exon 20. The mutant protein was constitutively active and expressed at physiologic levels in mammary gland, liver and heart in both the homozygous and heterozygous mutant mice. (J:157976)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
