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The Fabp4-LEP transgene was designed with the mouse aP2 promoter driving the expression of the human leptin (LEP) gene. Fabp4-LEP consists of, from 5' to 3', an aP2 promoter/enhancer, rabbit beta-globin, human leptin cDNA, and human growth hormone (hGH) polyadenylation (polyA) signal. One line, F8, was generated. Expression of the transgene was detected in brown adipose tissue, all white adipose tissue depots and in macrophages. (J:67311)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
