Log In|Sign Up
EN
Exon 8 was replaced with a floxed neo cassette and a modified exon 8 that contains a C to T transition producing a termination codon instead of glutamine at position 307 (Q307X), modeling genetic lesions observed in patients with leukemia and myeloproliferative disorders. Cre-mediated excision driven by the Tg(Prm-cre)70Og transgene carried by the parental PC3 ES cells removed the neo cassette upon transmission from male chimeras. (J:157660)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
