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The complete EGFP coding sequence was inserted in-frame in the first coding exon followed immediately by a cassette containing three stop codons. This same stop codon cassette was also inserted in exon 5 near its 5' end. An FRT site flanked neomycin resistance gene cassette was inserted 246 bp 5' of exon 1 as well. Chimeric mice were subsequently mated to an flp-deleter strain to excise the neo selection cassette. The full length endogenous protein is not expressed. (J:157377)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
