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A single nucleotide change was introduced within exon 12 resulting in an amino acid substitution K661R and codons 992-994 were deleted by homologous recombination. In addition a floxed neomycin phosphotransferase cassette was inserted in intron 11 and an FRT flanked hygro cassette was inserted within exon 17 by homologous recombination. The selection cassettes have been removed by flp and cre mediated recombination. (J:157019)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
