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A single nucleotide change was introduced within exon 12, resulting in amino acid substitution K661R, and a floxed neomycin phosphotransferase cassette was inserted within intron 11 by homologous recombination. This change is expected to disrupt the kinase activity. The selection cassette has been removed by cre mediated recombination. (J:157019)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
