Log In|Sign Up
EN
A rat heme oxygenase (decycling) 1 cDNA (nucleotide -14 through the poly[A] tail) was placed downstream of a 1.8 kb genomic DNA fragment containing the rat neuron-specific enolase (enolase 2, gamma neuronal) promoter. Homozygous transgenic mice exhibit elevation of Hmox1 mRNA and protein expression and enzyme activity. The increase in mRNA is modest in brain (115% of control level) and robust in spleen (200% of control level); no significant change in Hmox1 mRNA expression is detected in liver, kidney or testis. In situ hybridization and immunohistologic analysis demonstrates elevated Hmox1 expression in various regions of the brain. (J:120240)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
