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A loxP site and a neo cassette within intron 25 and an additional loxP site within intron 29 were added by homologous recombination. Cre-mediated recombination removed the floxed region. Translation of the mutant mRNA is predicted to produce a truncated protein with a scrambled sequence of 15 amino acids and a premature stop. Quantitative RT-PCR showed that transcript level was five fold lower in the mutant than in the wild-type. (J:157059)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
