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The transgene contains a modified rat BAC RPCI31.78K09 with the rat Notch3 gene carrying the CADASIL-associated mutation R169C. Two lines were created (88 and 92). Line 88 exhibit a 4-fold increase in expression and was selected as the representative line. (J:156682)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
