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A loxP site was inserted upstream of exon 3, and a pgk-neo cassette flanked by FRT sites as well as a second loxP site were targeted downstream of exon 7. Chimeric mice were produced from two recombinant ES cell clones. Exons 3-7 were excised by Cre mediated recombination. Western blot, immunostaining and RT-PCR showed no protein or RNA were detectable in the mutant testis. (J:156018)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
