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The human monoclonal antibody 2F5 was targeted into the J region removing J1 through 4 to produce chimeric human/mouse 2F5 antibodies. A floxed neo cassette used for ES cell selection was removed by cre mediated recombination. The 2F5 antibody is a polyreactive and broadly neutralizing antibody that protects against simian HIV challenge. (J:155798)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
