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The BAC clone RP24-283N8 containing 32 kb of 5'flanking sequence plus the first 6 exons of the murine Ebf2 gene was modified to insert the cDNA encoding a fusion of EGFP and the improved cre recombinase (icre) followed by the SV40 polyA signal into the first coding exon of Ebf2. This modified BAC was microinjected into the pronuclei of FVB/N oocytes. Founders were isolated and a line was established. The icre transcript distribution recapitulates that of endogenous Ebf2 transcripts at all locations and stages assayed. (J:156632)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
