The mutant allele was generated by deleting a sequence covering exon 1, which includes the start codon and the DM binding domain of the encoded protein. A loxP-flanked neomycin selection cassette replaced a part of exon 1, and the cassette was subsequently removed via cre-mediated recombination. (J:187218)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count