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The CD68-rtTA-M2 transgene was designed with a 2.9 kb promoter sequence from the human CD68 gene followed by a 83 bp fist intron (IVIS), a modified reverse tetracycline-regulated transactivator (rtTA) gene (from plasmid pUHRT-62-1), and bovine growth hormone polyA tail. This 4.5 kb transgene was microinjected into the male pronuclei of two cell (C57BL/6 x CBA) mouse zygotes. Founder line 3 (CD68-MP3) was established and backcrossed to C57BL/6 mice for at least 11 generations. The insertion site has been mapped to Chr 1. (J:154457)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
