Ryr1^tm1.1Dhm

A targeting vector was designed to insert a t14693c mutation into exon 102 that results in the amino acid substitution of threonine for isoleucine at position 4895 (I4895T). An additional silent substitution (g14697t) was introduced to aid in genotyping and allele expression studies. A neomycin selection cassette originally inserted in intron 101 was removed by cre mediated recombination. (J:127629)