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This transgene consists of a FLAG-tagged version of human HDAC5 expressed from a tetracycline responsive promoter. In addition serine-to-alanine mutations, at residues 259 and 498, were created to prevent the export of the protein to the cytosol. This transgene acts as a dominant-negative regulator of myocyte enhancer factor-2 signaling. (J:81967)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
