Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte

This transgene is composed of two constructs containing the Thy1 promoter driving expression of human PSEN1 with the amino acid substitution of valine for methionine at position 146 and human APP with the Swedish familial Alzheimer disease mutation (K670N, M671L). Line 10 (also known as 10-279) was selected as the representative line. (J:155410)