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The HSA-natLSP-IL15 transgene was designed with a modified human skeletal actin (HSA or ACTA1) promoter fragment (bases -2139 to +239), murine long signal peptide (LSP) isoform interleukin-15 (Il15) cDNA, and polyA signal. This transgene was microinjected into C57BL/6 x C3H hybrid oocyte pronuclei. Founder mice were identified and bred with C57BL/6J mice to establish line 10941 (with a stable single transgene insertion point). IL-15 mRNA/protein expression in skeletal muscle is approximately 300-fold/400-fold greater in hemizygous males and approximately 100-fold/400-fold greater in hemizygous females, respectively. (J:145611)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
