The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 1033bp between positions 32080026-32081058 of Chromosome 18 (Build GRCm39). The Gpr17 gene is nested inside Lims2 in the reverse strand such that its single coding exon is fully contained in the long intron 4 of Lims2. The lacZ and floxed neomycin selection cassette were inserted in frame after Gpr17's ATG without deleting any exons from Lims2. No Gpr17 mRNA was detected in the hypothalamus of homozygous mutant mice. (J:136110, J:219560)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
C57BL/6NTac
Targeted
Insertion, Intragenic deletion
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1
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1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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