A loxP site was inserted upstream of the translation initiation site and a floxed neo cassette followed by a lacZ gene with nuclear localization sequence was inserted downstream of exon 1. Reduced transcript expression was confirmed by northern blot analysis. (J:155607)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count