A floxed neo cassette was inserted 30 bp downstream of the translation initiation site. Cre mediated recombination removed the neo cassette leaving a single loxP site. The absence of COX activity was confirmed in E8.5 embryos. (J:155116)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count