Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz

A construct containing a Thy1 promoter driving expression of the human APP with the Swedish familial Alzheimer disease mutations (K670N, M671L) was co-injected with a construct containing the Prnp promoter driving the expression of human PSEN2 with the familial Alzheimer disease mutation N141I. Line 152H was used in subsequent experiments. (J:88193, J:154969)