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A construct containing a Thy1 promoter driving expression of the human APP with the Swedish familial Alzheimer disease mutations (K670N, M671L) was co-injected with a construct containing the Prnp promoter driving the expression of human PSEN2 with the familial Alzheimer disease mutation N141I. Line 152H was used in subsequent experiments. (J:88193, J:154969)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
