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A 345 bp fragment containing the 3' UTR was replaced with an 855bp fragment containing the rabbit beta-globin 3' UTR and a self-excising neo cassette via homologous recombination. The self-excising neo resistance cassette was then removed during germline transmission. Quantitative RT-PCR showed that the steady-state message levels were increased in adipose tissue, kidneys, liver and heart in homozygous and heterozygous mice compared to wild-type littermates. Real-time RT-PCR indicated that the transcripts from the knock-in allele were more stable than those from the wild-type allele. (J:154767)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
