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The tetracycline response element was used to drive inducible expression of the human gene with 77 CAG repeats. Five lines were created (lines 2909, 2776, 2285, 2904, and 2723) with different transgene copy numbers and CAG repeats. Line 2904 contains three copies of the transgene with 60, 65, and 80 CAG repeats per copy. This line also exhibits the highest level of protein expression. (J:154079)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
