A loxP site was inserted upstream of exon2 and an frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 2. Germ line, flp mediated recombination removes the neo cassette leaving exon 2 floxed. (J:154659)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count