Log In|Sign Up
EN
The transgene construct has the human cytomegalovirus immediate early promoter enhancer with chicken beta-actin/rabbit beta-globin hybrid promoter (CAG; from the pCAGGS vector) driving expression of a 1.8 kb fragment encoding the human CYP27A1 (cytochrome P450, family 27, subfamily A, polypeptide 1) cDNA sequence. This transgene was microinjected into the pronuclei of fertilized mouse eggs taken from superovulated CBA females. The highest transgenic overexpressor founder mouse (23) was bred to wildtype C57BL/6J (Harlan) mice to establish line 23. (J:78951)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
