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Residues Y315 and Y319 present in exon 7 of ZAP-70 were mutated to alanine. A diagnostic EcoRV site was also introduced into exon 7 as well as a floxed neo cassette in intron 2. Cre mediated recombination in the male germline subsequently removed the neo cassette. (J:154166)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
