An frt flanked neo cassette with a 3' loxP site was inserted upstream of exon 1 and an additional loxP site was inserted downstream of exon 3. Germ line, flp mediated recombination removed the neo cassette leaving exons 1 through 3 floxed. (J:154611)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count