The targeting construct contains a CMV promoter followed by a LoxP66 site, a cDNA encoding an antisense mouse Bmi1, an IRES, an eGFP cassette and a LoxP71 followed by a PGK promoter neo cassette. Cre expression enables the inversion of the antisense Bmi1. (J:187257)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count