Log In|Sign Up
EN
Exon 1 was replaced with a modified exon 1 in which the codons corresponding to the residues 85 through 88 (the R-Smad binding site) and 266 through 267 (the Co-Smad binding site) were altered to code for alanines. A floxed neo cassette was inserted downsteam of the modified exon 1 and subsequently removed by germ line, cre mediated recombination. This allele is predicted to produce a protein product incapable of interacting with R-Smads and Smad4. (J:154718)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References Literature
Title
PMID
Journal
Year
IF
