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The collagen X promoter was ligated upstream of the cDNA sequence encoding the myc-tagged cog mutant form (a C to T transition yielding a leucine to proline change at residue 2263) of thyroglobulin (Tg). This line has 5 copies of the transgene at a single insertion site and expressed 17% and 33% the level of endogenous collagen X in the hemizygous and homozygous state, respectively. Expression of Tg protein in hypertrophic chondrocytes did not affect the normal secretion of collagen X. (J:154052)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
