A gene trap vector consisting of long terminal repeats flanking a construct with pairs of FRT, F3, loxP and lox5171 sites surrounding a splice acceptor-neo-polyA cassette was inserted in intron 2. qRT-PCR analysis indicates that mRNA is diminished by 80-90% in homozygotes, indicating this is a strong hypomorphic allele. (J:221782)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129P2/OlaHsd
Gene trapped
Insertion of gene trap vector
--
1
4
6

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

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PMID
Journal
Year
IF
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