Tbx21^duane

ENU mutagenesis induced a point mutation (T to A chr 11: 96973058) in the second intron altering the splice acceptor site and thereby preventing normal splicing. This mutation deletes 8 amino acids from the final peptide. Activated splenocytes exhibit a 3- to 4-fold decrease in protein expression compared with similarly treated wild-type cells. (J:154069)