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This transgene contains the mouse glial fibrillary acidic protein promoter driving the expression of an RU486-inducible Cre recombinase. The encoded protein is a fusion of Cre recombinase with a mutant human progesterone receptor that fails to bind to its natural ligand at physiologic concentrations but does bind to the synthetic progesterone analog RU486. The unbound fusion protein is restricted to the cytoplasm; it can enter the nucleus only when bound to RU486. (J:115216)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
