Kcnh5^{tm1(cre/PGR*)Mim}

The endogenous gene's promoter drives expression of a DNA sequence encoding a fusion protein in which Cre recombinase is joined to the ligand binding domain (LBD) of the human progesterone receptor lacking the carboxyl terminal 42 amino acids. The chimeric recombinase protein is not constitutively active; its activity is inducible by binding of the synthetic progesterone analog RU486 to the truncated progesterone LBD. (J:104881, J:122587)