A loxP site was inserted upstream of exon 12, and a floxed neo cassette was inserted downstream of exon 12. Germ line, cre mediated recombination removes the neo cassette leaving exon 12 floxed. (J:153841)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count