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The protion of the gene encoding the metalloprotease-cleavage site was mutated (SSFEKQI to SEEAAAI) preventing the production of the soluble peptide. However, the membrane version is still produced. The floxed neo cassette used for selection purposes was removed by germ line, cre mediated recombination. (J:153501)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
