A loxP site was inserted upstream of exon 45 and a myc tag, a loxP site, an HA tag, and an frt flanked neo cassette were inserted downstream of exon 46. Germ line, flp mediated recombination removed the neo cassette leaving exons 45 and 46 floxed. (J:153606)
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count