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The starting ATG codon as well as codons 2-4 of exon 1 were replaced with a lacZ-floxed PGKneo cassette. The neo cassette was in the same transcriptional orientation as the gene itself. In vivo cre excision was accomplished by crossing to Tg(ACTB-cre)2Mrt transgenic mice. After cre excision of neo, beta galactosidase staining was reduced in intensity but the overall pattern of staining was maintained. (J:71309, J:157446)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
